Random Positioning Machine


Price: Leasing from €10.000
In Stock
Shipped anywhere worldwide.

Domains: stem cell research cell biology tissue engineering regenerative medecine

The Random Positioning Machine simulates microgravity by continuously changing the orientation of samples.

  • Provides micro- and partial gravity simulations between 0g and 0.9g for scientific, educational and industrial applications.
  • Compact design to support experiments in radiation and incubator facilities (temperature, CO2, humidity environments).
  • Includes software for controlling and monitoring multiple parameters, such as the average gravity level.
  • Unique and proven path algorithms with protection against so-called pole bias.
  • Option to power an experiment system on the experiment platform, allowing for instance illumination, monitoring, perfusion, activation/fixation observation etc.
  • Multiple motion modes supported, including: partial-g, random speeds, clinostat and more.

  • Newest instrument version with partial gravity support (from 0g up to 0.9g).
  • Laptop with pre-installed RPM control software and user manual.
  • Shipping container and transport to your location.
  • Expert performs on-site installation and provides a Random Positioning Machine workshop.
  • A yearly check-up for optimal performance.
  • After renting it is possible to purchase the Random Positioning Machine for a favourable price.

The rotation minimizes the influence of Earth’s gravity on samples inside the device. These simulations enable to research for example the influence of gravity on biological organisms, such as plants and humans.

A sample container, which is connected to two independent axes, is rotated by the machine with random speeds in all directions. Due to the random motion, the sample experiences gravity from every direction. Thus, after some time the average of the gravity affecting the sample goes to zero. In this way, the RPM simulates microgravity for objects inside its container. This is sometimes also referred to as 3D clinostat.

The RPM 2.0 also simulates ‘partial gravity’. This provides all gravity levels from 0g up to 0.9g. Partial gravity is achieved by changing the random motion pattern in such a way that on average the sample experiences some influence of Earth’s gravity. It is used for simulating e.g. the 0.38g Mars’ gravity or 0.17g Moon’s gravity, but also for determining e.g. the gravity level at which organisms or cells change behavior.

Related investigations

Life Science, Cell- and Microbiology

Gravity has many important effects on cells and introducing microgravity allows new cell-, micro- and mechanobiology research. For example, microgravity leads to different intra- and inter-cell communication, changes in genetic expression, cell growth and shape, gravitropism and mechanosensitivity effects, etc.

The use of the random positioning machine for the study of gravitational effects on signal transduction in mammalian cells
Daniela Grimm et al., 2006

Chiral and non-chiral nutations in Arabidopsis roots grown on the random positioning machine
S. Piconese et al., 2003

Using space-based investigations to inform cancer research on Earth
Jeanne L. Becker & Glauco R. Souza, 2013

Regenerative Medicine, Tissue Engineering and Stem Cell Research

Recently published papers describe the use of RPM for regenerative medicine and 3D tissue engineering / cell culturing. For example, research has shown that microgravity can be used to reduce differentiation of stem cells.
“In summary, it can be concluded that the formation of multicellular spheroids is occurring in thyroid cancer cells as well as in normal cells, a finding, which shows that simulated microgravity is a usable approach for engineering functional tissue. These functional tissues might be used in the future for pharmacological testing or co-culture experiments to investigate neoangiogenesis inhibitors, yielding a more accurate picture than mouse or rat models.”

Mechanisms of three-dimensional growth of thyroid cells during long-term simulated microgravity
Sascha Kopp et al., 2005

Tissue Engineering of Cartilage on the Random Positioning Machine
Ganna Aleshcheva, 2014

Growing tissues in microgravity
Brian R. Unsworth & Peter I. Lelkes, 1998

Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells
Elizabeth A. Blaber et al., 2015

Summary


Platform

Microgravity Simulator

Facility

Random Positioning Machine

Price estimation

Leasing from 10.000 €

Services included

Shipping
On-site training
Six months of use